Is GAE Painful? A Guide to Comfort During the Procedure

When you’re living with chronic knee pain, the thought of any medical procedure—even one designed to bring relief—can be intimidating. One of the first and most common questions patients ask is: “Will it hurt?” This is especially true for a newer, less familiar treatment like Genicular Artery Embolization (GAE). You’re already in pain; the last thing you want is a procedure that causes more of it.

The good news is that GAE is specifically designed to be a comfortable, minimally invasive experience. Unlike major surgery, which involves large incisions and significant trauma, the GAE procedure is a sophisticated, gentle technique that prioritizes patient comfort from start to finish. The overwhelming majority of patients report feeling little to no discomfort during the entire process.

At Fox Vein and Vascular, ensuring a painless and stress-free experience is a cornerstone of our care philosophy. Dr. David Fox, a board-certified vascular surgeon with extensive expertise, utilizes advanced techniques to make your GAE treatment as comfortable as possible. This guide will walk you through each step of the process, explaining exactly what you can expect to feel—and not feel—during and after your GAE procedure.

Understanding the “Minimally Invasive” Philosophy

To understand why GAE is not a painful procedure, it’s helpful to grasp what “minimally invasive” truly means. It’s a medical philosophy centered on achieving therapeutic goals with the least possible trauma to the body.

• Traditional Surgery (Maximal Invasion): A total knee replacement involves an 8- to 12-inch incision, cutting through skin, muscle, and tendon, sawing off the ends of bones, and hammering in a metal and plastic prosthesis. This is a highly traumatic event for the body, which is why the recovery is long and often very painful.
• GAE (Minimal Invasion): GAE works from the inside out. It uses the body’s natural arterial pathways to deliver treatment precisely where it’s needed. The only break in the skin is a tiny puncture, about the size of a spaghetti noodle, through which a catheter is inserted. There is no cutting of muscle, no removal of bone, and no large wound to heal.

This fundamental difference in approach is the primary reason why the pain profile of GAE is so vastly different from that of surgery.

During the GAE Procedure: What to Expect Step-by-Step

The GAE procedure itself typically lasts between 45 and 90 minutes. You will be in a state-of-the-art procedure suite, and a team of medical professionals will be dedicated to your comfort and safety throughout.

Step 1: The Prep and “Twilight Sedation”

Before anything begins, you will be made comfortable on the procedure table. An IV line will be placed in your arm, through which you will receive medication for what is known as “conscious sedation” or “twilight sedation.”

• What it is: This is not general anesthesia. You will not be unconscious or have a breathing tube. You will be in a deeply relaxed, sleepy, and dream-like state. Many patients doze off and have little to no memory of the procedure afterward.
• What you’ll feel: You will feel calm and relaxed. The medication eliminates anxiety and any potential discomfort. You will be breathing on your own and able to communicate with the medical team if needed, but you will likely feel pleasantly detached from the process.

This sedation is a key component of ensuring a painless experience. It’s the same type of sedation used for common procedures like a colonoscopy.

Step 2: The Access Site and Local Anesthesia

Once you are sedated, Dr. Fox will prepare the access site. This is the spot where the catheter will enter your artery, usually in the upper thigh (groin) or near the ankle.

• What is done: The area is meticulously cleaned, and a local anesthetic (like lidocaine) is injected into the skin and underlying tissue. This is the same type of numbing medication a dentist uses before filling a cavity.
• What you’ll feel: You might feel a brief, tiny pinch or a slight stinging sensation as the local anesthetic is administered. This feeling lasts for only a few seconds. After that, the entire area will be completely numb. You will not feel the small puncture that is made to insert the catheter. This is often the only distinct sensation patients report feeling during the entire procedure.

Step 3: Catheter Navigation

With the access site numb and you comfortably sedated, Dr. Fox will insert a slender, flexible tube called a catheter into the artery. Using advanced, real-time X-ray imaging (fluoroscopy) as his guide, he will expertly navigate this catheter through your arterial system to the small genicular arteries that surround your knee.

• What you’ll feel: Nothing. Your arteries do not have nerve endings on their inner walls. As the catheter moves through your body, you will be completely unaware of its presence. There is no sensation of movement, pressure, or pain associated with this part of the procedure. You will likely be dozing comfortably.

Step 4: Mapping and Embolization

When the catheter is in position near the knee, a contrast dye is injected. This dye acts as a roadmap, lighting up the arteries on the X-ray screen and allowing Dr. Fox to identify the specific abnormal vessels that are feeding the inflammation. Once these targets are confirmed, tiny, sand-like particles (embolization beads) are released through the catheter.

• What you’ll feel: Some patients report feeling a temporary, mild, warm sensation in or around their knee as the contrast dye is injected. This is not painful and passes in a few moments. Most patients, deep in twilight sedation, feel nothing at all. You will not feel the microscopic beads being released or blocking the tiny vessels.

Step 5: Completion

After the embolization is complete, the catheter is withdrawn, and a small bandage or closure device is placed over the tiny puncture site. The procedure is over.

To summarize, for the vast majority of patients, the GAE procedure is a painless experience. The combination of powerful local anesthesia and relaxing twilight sedation ensures comfort and eliminates anxiety.

After the Procedure: The Recovery Experience

The comfort of the GAE experience extends into the recovery period, which is remarkably mild compared to surgery.

The First Few Hours (Immediate Post-Procedure)

After the procedure, you will be moved to a recovery area to rest for a short period as the sedation wears off. Nurses will monitor you to ensure you are waking up comfortably.

• What you’ll feel: You will likely feel a bit groggy from the sedation. There may be some mild soreness or a feeling of pressure at the access site (groin or ankle), similar to the feeling after having blood drawn. Your knee itself should not be painful. You will be able to get up and walk within an hour or two.

The First 24-48 Hours (At Home)

You will be discharged home the same day. Most patients are back to their normal daily activities, like walking and light household chores, within a day or two.

• What you’ll feel: The most common sensation is mild bruising and tenderness at the puncture site. This can be easily managed with an ice pack and over-the-counter pain relievers like Tylenol if needed.
• Post-Embolization Syndrome: A small number of patients may experience what is called post-embolization syndrome. This can include a temporary, short-lived increase in knee pain, a low-grade fever, or flu-like symptoms. This is a normal sign that the body is responding to the inflammation being shut down and typically resolves on its own within a few days. It is a positive indicator that the treatment is working. It can be managed with standard anti-inflammatory medications like ibuprofen.

The First Few Weeks (Noticing the Improvement)

This is when the magic of GAE starts to become apparent.

• What you’ll feel: The initial procedure-related soreness will fade completely. As the inflammation in your knee joint continues to decrease, you will begin to notice a significant reduction in your chronic osteoarthritis pain. This improvement is usually noticeable within one to two weeks and continues to build over the next several months. You’ll find yourself walking with less pain, climbing stairs more easily, and sleeping more soundly.

This pain-free window is the ideal time to begin gentle exercises that support GAE outcomes and consider a program of physical therapy to enhance your results.

Why Expertise Matters for a Painless Procedure

While the GAE procedure is inherently designed for comfort, the skill of the physician performing it plays a significant role. Choosing a highly experienced vascular surgeon like Dr. David Fox ensures the most gentle and efficient procedure possible. For more information about Dr. Fox and our dedicated staff, visit our Fox Vein and Vascular team page.

• Efficiency: An experienced operator can perform the procedure more quickly and with greater precision, which means less time under sedation and less manipulation of tissues.
• Catheter Skills: Dr. Fox’s two decades of experience in navigating complex arterial anatomy means he can guide the catheter smoothly and atraumatically to its target.
• Pain Management Protocol: At Fox Vein and Vascular, we have a refined protocol for sedation and local anesthesia to maximize patient comfort at every stage. We are proactive about preventing pain, not just reacting to it.

Our entire team, from the nurses to the technicians to Dr. Fox himself, is dedicated to making our patients from Manhattan, the 5 Boroughs, Nassau, Suffolk, South Western Ct., and North East NJ feel safe, informed, and comfortable.

GAE: The Comfortable Path to Knee Pain Relief

The fear of pain should not hold you back from seeking relief from your chronic knee osteoarthritis. Genicular Artery Embolization stands in stark contrast to the painful, lengthy recovery associated with knee replacement surgery. It is a sophisticated, evidence-based procedure where patient comfort is a top priority.

From the anxiety-reducing sedation to the powerful local anesthesia, every step is designed to be a painless and positive experience. The minor, short-lived discomfort of recovery is a small price to pay for the profound and long-lasting relief from chronic knee pain that follows. If you are a good candidate for GAE, you can look forward to a treatment journey that is as comfortable as it is effective.

Stop letting the fear of pain dictate your life. Schedule a consultation with Dr. Fox to discuss a comfortable, non-surgical solution for your knee pain.

Fox Vein and Vascular – Manhattan, NY
📞 (212) 362-3470
🌐 foxvein.com
📍 1041 Third Avenue, New York, NY 10065